While some of the most potent CTSV inhibitors identified could also target CTSL, compound 7 from the study did show selectivity towards CTSV and examination in cell-based assays illustrated its ability to attenuate MCF-7 tumour cell proliferation, in line with our observations herein using shRNAs (Mitrović et al., 2022). The gene discussed is CTSV; the disease is neoplasm.