IL-1β plays a pivotal role in connecting innate and adaptive immune responses (Ghiringhelli et al., 2009), inducing the polarization of IFN-γ-secreting CD8+ T cells and triggering the formation of IL-17-producing γδT cells, which γδT cells have the ability to recognize tumor-associated antigens and perform anti-cancer activities (Ma et al., 2011). This evidence concerns the gene CD8A and neoplasm.