On the other hand, elevated levels of ABCB1 have also been shown to be associated with paclitaxel resistance in human osteosarcoma (OS) cell lines, which developed cross-resistance with other ABCB1 substrates, such as doxorubicin, docetaxel, and vincristine (Yang et al., 2014). The gene discussed is ABCB1; the disease is osteosarcoma.