STAT3 and breast cancer: For example, in the study carried out by Lu L et al. (Lu et al., 2018), in the MB-468 radioresistant breast cancer cell line, they observed low levels of ROS and higher levels of STAT3 and Bcl-2 proteins; on the other hand, when they added Niclosamide, a potent STAT3 inhibitor, radioresistance was overcome by inhibiting STAT3 and Bcl-2 and inducing ROS (Lu et al., 2018).