Nestal de Moraes et al. (Nestal de Moraes et al., 2015) demonstrated that the transcription factor FOXM1 upregulates the expression of the anti-apoptotic genes XIAP and Survivin, which contributes to the development of drug resistance and is associated with poor clinical outcomes in breast cancer patients (Nestal de Moraes et al., 2015). The gene discussed is BIRC5; the disease is breast carcinoma.