However, it has been shown in an orthotopic mouse model of human pancreatic cancer that RSV enhanced the antitumor activity of gemcitabine, and this was associated with decreased expression of Bcl-2, Bcl-xL, COX-2, cyclin D1, MMP-9 and VEGF (Harikumar et al., 2010). This evidence concerns the gene PTGS2 and familial pancreatic carcinoma.