Clinical studies have found that serum ELA levels are reduced in patients with DKD and are significantly negatively correlated with urinary albumin/creatinine ratio (ACR) and serum creatinine, suggesting that the molecules is involved in the progression of DKD (Zhang et al., 2018).Therefore, the decrease in serum ELA levels may be a clinical predictive indicator for DKD patients, and may also become a new therapeutic drug for preventing or delaying the progression of DKD. Here, ALB is linked to diabetic kidney disease.