AKT1 and neoplasm: In the in vivo animal experiments, subcutaneous injection of ELA into kidney cancer model mice decreased the tumor growth in mice bearing ELA tumors (Soulet et al., 2020; Liet et al., 2021) ELA-11, ELA-32, and mut ELA-32 induced mTORC1 activation, inhibited ERK and AKT activation, and promoted apoptosis of renal cancer cells to exert anti-tumor effects.