No immunoreactivity to ELA was detected in Fuhrman grade 1 and 2 clear cell renal cell carcinoma, while that in Fuhrman grade 3 and 4 clear cell renal cell carcinoma was significantly lower than that in normal kidney tissue and that in grade 4 clear cell renal cell carcinoma was significantly higher than that in grade 1, 2, and 3 (Artas et al., 2019). The gene discussed is APELA; the disease is clear cell renal carcinoma.