The significant overexpression of FAP in cancer-associated fibroblasts (CAFs) in more than 90% of epithelial tumors, including HNCs, while being scarcely detectable in healthy adult tissues, has led to the development of PET imaging using radiolabeled FAP inhibitors (FAPIs) in the field of nuclear medicine (Hamson et al., 2014; Li et al., 2022). The gene discussed is FAP; the disease is cancer.