Hypoxia regulates the expression of molecules such as p53 (Liu et al., 2019), pyruvate kinase type M2(PKM2) (Luo et al., 2011), and HIF -1α (Gillies, 2022) in tumour cells, thus altering the glycolytic metabolism of the tumour and the expression of proteins. This evidence concerns the gene TP53 and neoplasm.