HIF1A and cancer: In 2021, Zheng et al. constructed a microarray model of lung cancer liver metastasis in hypoxic conditions, explored the effect of hypoxia on hypoxia-inducible factor 1α (HIF -1α), and evaluated the therapeutic effects of HIF-1α inhibitors, tirapam, SYP-5, and IDF-11774, on cancer invasion (Zheng et al., 2021).