In vivo experiments, the average tumor volumes for Gem NPs, MUC1 inhibitor NPs, Gem-MUC1 inhibitor NPs, blank NPs, 5-FU, and sterile saline were approximately 828.75, 747.07, 473.75, 1055.14, 373.92, and 1119 mm3, respectively. Here, MUC1 is linked to neoplasm.