How might your results change the direction of research or the focus of clinical practice? A lower cut-point for BNP/NT-proBNP may be relevant when diagnosing acute heart failure in obese PWH who may be at particular high risk of both natriuretic peptide deficiency and heart failure and may present with lower-than-expected levels of natriuretic peptides. The gene discussed is NPPB; the disease is heart failure.