Increasing BMI was associated with 6% higher odds of low NT-proBNP per 1 kg/m2 increase in BMI, both when adjusting for sex and age (OR 1.06 [95% CI: 1.02–1.10], p=0.004) and after further adjustment for smoking, diabetes, hypertension, eGFR, and HCV antibodies (aOR 1.06 [1.01–1.11], p=0.009) (Table 2). The gene discussed is NPPB; the disease is diabetes mellitus.