Interestingly, the majority of ALS-mutations, located in the C-terminal domain (reviewed in Buratti, 2015; Prasad et al., 2019), modulate the ability of TDP-43 to induce LLPS (Conicella et al., 2016) and may promote cytoplasmic aggregate formation, disrupting the subcellular transport and localization of its target mRNAs. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.