SOD1 and amyotrophic lateral sclerosis: Prdx2 is temporarily upregulated in the spinal cord of presymptomatic SOD1 mice (Pharaoh et al., 2019) and in surviving ALS patients’ motoneurons at an intermediate disease stage, while at late stages the breakdown of this antioxidant system accelerates neuronal death (Kato et al., 2005).