Pathologically phosphorylated tau fibrils, either bearing unique phospho-epitopes or evident as an increase in total tau phosphorylation, is a neuropathological hallmark of various neurodegenerative diseases, including CTE (Corsellis et al., 1973; Omalu et al., 2005; McKee et al., 2009; Kanaan et al., 2016), ALS with cognitive impairment (ALSci) (Yang et al., 2003; Strong et al., 2006; Yang and Strong, 2012) and Alzheimer’s disease (Grundke-Iqbal et al., 1986; Goedert et al., 1989; Hasegawa et al., 1992). Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.