By using an HFD-induced obesity model, their results showed a reduction in TH levels and an elevation in TH phosphorylation in the ventral tegmental area, which was not linked with α-synuclein, but with obesity-induced insulin resistance, inflammation, oxidative stress, and activation of astroglia and microglia. The gene discussed is SNCA; the disease is obesity due to melanocortin 4 receptor deficiency.