Alongside NGF and BDNF alterations, hyperleptinemia and an increased number of mast cells in subcutaneous abdominal adipose tissue are also reported (Sornelli et al., 2007; Tore et al., 2008), shedding light on the role of these metabotrophins in the pathogenesis of obesity and related diseases. The gene discussed is BDNF; the disease is Obesity.