The receptor for this cytokine (LepR) has been found to be overexpressed both in CD8+ T cells, as well as in monocytes during the acute phase of the disease (Frisullo et al., 2007) and leptin has been found at high levels in CNS lesions of MS post-mortem samples (Lock et al., 2002). The gene discussed is LEP; the disease is myeloid sarcoma.