Studies have shown decreased levels of NGF and BDNF in conditions like metabolic syndrome, acute coronary syndromes, and obesity, suggesting their potential involvement in the development of atherosclerosis and metabolic disorders (Tore et al., 2008; Yanev et al., 2013; Frohlich et al., 2021). This evidence concerns the gene BDNF and obesity due to melanocortin 4 receptor deficiency.