IDH2 and neoplasm: As such, IDH mutations may reduce tumor growth rate either because of reliance on a slower metabolic process in oxidative phosphorylation rather than the more rapid glycolysis, or because D2HG prevents complete reductive carboxylation of glutamine to citrate and ultimately lowers cytosolic acetyl-coA availability for cholesterol and phospholipid synthesis, amino acid modifications, and histone acetylation needed to undergo rapid cellular division (Grassian et al., 2014; Fack et al., 2017; Han et al., 2020).