Furthermore, HIF-1α stabilization also upregulates GLUT1 and GLUT3 transporter expression and phosphofructokinase (PFK1) expression, allowing for elevated glucose uptake, increased glycolytic capacity, and rapid production of the ATP needed to sustain the high metabolic demand of glioma cells (Han et al., 2020). The gene discussed is HIF1A; the disease is central nervous system cancer.