Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) are recommended as essential indicators for the diagnosis of PJI by the American Academy of Orthopaedic Surgeons (AAOS) and the Musculoskeletal Infection Society (MSIS) guidelines due to their superior sensitivity and specificity (6, 7). This evidence concerns the gene CRP and juvenile polyposis syndrome.