Four known inflammasome-forming proteins, namely, NOD-like receptor family pyrin domain-containing 1 (NLRP1), NLRP3, absent in melanoma 2 (AIM2) and NOD-like receptor family caspase recruitment domain protein (CARD) domain-containing 4 (NLRC4), have been confirmed as inflammasome sensors in ischemic stroke with highlighted upregulation [68]. The gene discussed is NLRP3; the disease is ischemic stroke.