Next, several studies have revealed that multiple post-translational modification molecules, such as cylindromatosis (CYLD), chromatin immunoprecipitation (CHIP), Triad3A and ribosomal S6 kinase 3 (RSK3), have been implicated in stroke by mediating the activation of RIPK1 and RKPK3 [31–34]. Here, RIPK1 is linked to stroke disorder.