Moreover, similar to GSDMD, GSDME (originally identified as deafness autosomal dominant 5, DFNA5) contains a pore-forming domain in the N-terminal which is specifically cleaved by caspase-3 to form a pyroptosis pore in the plasma membrane and switches the activation of caspase-3 from driving an apoptotic program to causing pyroptosis [74]. Here, CASP3 is linked to deafness.