In MCAO mice, the nicotinamide adenine dinucleotide-dependent deacetylase Sirtuin 1 (Sirt1) reduced ischemic stroke-induced neuronal pyroptosis by inhibiting ROS and tumor necrosis factor receptor associated factor 6 (TRAF6) in hippocampal neurons [9], while valproic acid countered neuronal pyroptosis via apoptosis repressor with caspase recruitment domain (ARC)/caspase-1/GSDMD axis in cerebral ischemic injury [97]. The gene discussed is CASP1; the disease is ischemic stroke.