HAVCR2 and obesity due to melanocortin 4 receptor deficiency: In this study, after controlling for smoking, alcohol consumption and obesity influencing factors, the dose–response relationship between Mn internal exposure dose and TIM-3 was analyzed and it was found that the concentration of TIM-3 in the serum of the workers tended to increase with the increase of the internal exposure dose, which indicated that the measured circulating level of TIM-3 may be correlated with the dose of the toxic exposure, suggesting that TIM-3 has a potential value as a marker of the effect of Mn exposure.