Table 5 displays the results of the AUC with a 95% confidence interval in ROC analysis. The AUC of the NLR was 0.790 (95% CI: 0.689–0.891, p < 0.001), which was significantly greater than that of the CRP (0.780, 95% CI: 0.686–0.873, p < 0.001). Additionally, the AUC of PNI was a substantial predictor for DFU-induced sepsis (0.702, 95%CI: 0.619–0.785, p < 0.001). Here, CRP is linked to Sepsis.