MTOR and autosomal dominant polycystic kidney disease: Indeed, AMPK has been shown to inhibit cell proliferation in different models, via the inhibition of de novo lipogenesis,71,72,73,74 but also through the (in)direct modulation of pro- and anti-proliferative pathways, such as mTOR, Hedgehog, and Hippo, all pathways that have been shown to be overactive in ADPKD.10