,40,86 While no causal link has been reported between ADPKD pathogenesis and IMP concentrations, it has recently been shown that CDK7, part of a super-enhancer machinery upregulated in ADPKD, increases kidney IMP concentrations by upregulation of AMP deaminase 3 (AMPD3), and that treatment with the CDK7 inhibitor THZ1 or the AMPD3 inhibitor pentostatin suppresses cyst formation in PKD mouse models.87 This evidence concerns the gene AMPD3 and autosomal dominant polycystic kidney disease.