AMPD3 and cyst: ,40,86 While no causal link has been reported between ADPKD pathogenesis and IMP concentrations, it has recently been shown that CDK7, part of a super-enhancer machinery upregulated in ADPKD, increases kidney IMP concentrations by upregulation of AMP deaminase 3 (AMPD3), and that treatment with the CDK7 inhibitor THZ1 or the AMPD3 inhibitor pentostatin suppresses cyst formation in PKD mouse models.87