NFKB1 and atherosclerosis: Instead, we found that PF-06409577 induced reductions in atherosclerosis required AMPK β1 in myeloid cells and this dose dependently activated AMPK in bone marrow-derived macrophages (BMDMs) reducing cholesterol and fatty acid synthesis, lowering the expression of inflammatory response and I-kappaB kinase/NF-κB regulated transcripts and increasing the expression of transcripts important for autophagy.