These data show that PF-06409577 induced reductions in atherosclerosis were associated with the suppression of fatty acid and cholesterol synthesis, induction of markers of autophagy (increased ULK1 phosphorylation and Atg5, Atg12, and Lamp2) and the suppression of genes related to inflammatory responses, immune system processes, and IkappaB kinase/NF-κB signaling. Here, ATG12 is linked to atherosclerosis.