MID1 and eosinophilic esophagitis: Previous studies on tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) signaling in murine models of EoE have shown that inflammation and remodeling of esophageal tissue are dependent on the expression of TRAIL and downstream signaling through the E3 ubiquitin ligase Midline (MID)-1 (16, 17).