To assess the role of the TRAIL and MID-1 signalling processes in the allergic mechanisms driven specifically by IL-13 in EoE, we assessed MID-1 expression downstream of IL-13 administration in Tnfsf10−/− (TRAIL-deficient) mice and Stat6−/− (transcription factor governing propagation of Th2-mediated allergic inflammation). This evidence concerns the gene STAT6 and eosinophilic esophagitis.