For example, circ0040929,[12] circRNA oxysterol binding protein like 2 (circOSBPL2),[13] lncRNA lung cancer associated transcript 1 (LUCAT1),[14] and miR-125a-5p[15] show a more sensitive expression pattern in smokers with COPD than in those without COPD. The gene discussed is LUCAT1; the disease is chronic obstructive pulmonary disease.