Furthermore, lncRNA antisense non-coding RNA at the INK4 locus (ANRIL)[20] expression is decreased in COPD patients, especially those with acute exacerbations (AECOPD), while lncRNA nuclear-enriched abundant transcript 1 (NEAT1)[21] expression is increased. This evidence concerns the gene CDKN2B-AS1 and chronic obstructive pulmonary disease.