ARVCF and Norrie disease: Further, we did the effective-median-based Mendelian randomization for inferring the causal genes (EMIC) approach for ARVCF with the GWAS results from our sample and GTEx expression data in brain, we found that ARVCF is a causal gene for ND in forebrain region (min EMIC p = 0.021), suggesting that ARVCF overexpression might increase the risk of ND (Figure S3).