EDN1 and cancer: Most of the identified interactions are involved in angiogenesis (such as CCL28/CCR10, or VEGFA/FLT1 + KDR)24 or known to play a role in malignant and stromal cell proliferation (such as EDN1/EDNRB with endothelial cells, EDN1/EDNRA with fibroblasts, and all interactions targeting EGFR on cancer cells).25