Oncogenic signaling pathways, including B-Raf kinase (BRAF) and epidermal growth factor receptor (EGFR), drive dysregulation of fatty acid metabolism, affecting membrane composition and saturation to regulate tolerance to reactive oxygen species (ROS) and cancer cell survival (Talebi et al., 2018; Gimple et al., 2019; Bi et al., 2019). The gene discussed is EGFR; the disease is cancer.