In our study, we mainly focused on EOC, an epithelial ovarian cancer, and found that silent METTL3 could inhibit cell viability and proliferative capacity, promote apoptosis, and induce cell cycle arrest in the G0/G1 phase, indicating that METTL3 performed a similar role in EOC as it did in OC. This evidence concerns the gene METTL3 and ovarian carcinoma.