TP53 and neoplasm: However, the expression of paracancerous tissues in LGG patients was significantly reduced by 271.33 ± 52.07% at CASP9 (p < 0.001), 108.95 ± 20.35% at IL1A (p < 0.001), and 1,292.90 ± 527.72% at IL18 (p < 0.001), 2,496.74 ±  519.85% at TIRAP (p < 0.001), 9,446.02 ± 1,240.85% at TNF (p < 0.001), 6,240.67 ± 1387.22% at TP53 (p < 0.001), compared with the tumor tissues (Figs. 4M–4R).