Among the 33 tumor types, TMUB1 was significantly overexpressed in 23 tumors (Fig. 1A), particularly in gastrointestinal tumors (cholangiocarcinoma, colon adenocarcinoma, oesophageal carcinoma, liver hepatocellular carcinoma, rectum adenocarcinoma, and stomach adenocarcinoma). Here, TMUB1 is linked to digestive system neoplasm.