In this study, AKAP5 and SLC2A3 in a 7-gene signature were relevant to the mechanism of immune cell infiltration in GC.AOAH-IT1 is a recently identified molecular marker of tumor, and CTLA4, LRRC8C, AOAH-IT1, NPC2, and RGS1 are involved in immune response and serve as molecular markers for therapeutic targets, prognosis, and immune cell immune infiltration in cancer. This evidence concerns the gene AKAP5 and gastric cancer.