Subsequently, seven genes (AKAP5, CTLA4, LRRC8C, AOAH-IT1, NPC2, RGS1, and SLC2A3) were determined by multivariate COX analysis as the most prognostically relevant genes for GC and composed together as a 7-gene signature for characterizing the immune activity of GC. The gene discussed is AKAP5; the disease is gastric cancer.