On the other hand, some studies of genetic polymorphisms revealed that paraoxonase-1 L55M and Q192R genetic polymorphisms play important roles in microangiopathy susceptibility (Wu et al., 2018), and superoxide dismutase-2 (SOD2) CC genotype gives antioxidant protection against DKD (Oikonomou et al., 2018), and other various genetic polymorphisms in DMA have also been reviewed (Lyssenko & Vaag, 2023), suggesting that some polymorphic genes have specific clinical value in DMA assessment. The gene discussed is SOD2; the disease is diabetic kidney disease.