When categorized as number of drugs used <10 and g10, the 6th-month median DAS-28 CRP scores were 2.83 (1.69) and 3.81 (1.82) in the RA patients with and without polypharmacy, and their 12th-month DAS-28 CRP scores were 2.4 (1.42) and 4.76 (2.92), respectively; where the differences between the groups created based on the numbers of drugs the patients used were statistically significant difference was found between them (p = 0.044 and 0.012, respectively). Here, CRP is linked to rheumatoid arthritis.