To validate the regulatory network of circMMP11-miR-361-3p-HMGB1 pathway, we examined the protein levels of HMGB1 in HCC cells after treating with miR-361-3p inhibitor (miR30017075-4-5, in vivo, 5 nmol, RiboBio, Guangzhou, China)/si-circMMP11 alone or in combination. The gene discussed is HMGB1; the disease is hepatocellular carcinoma.