It was found that stem cell differentiation-related pathways, including stem cell differentiation and stem cell population maintenance, were significantly enriched in gastric cancer with high expression of KMT2A; meanwhile, a significant correlation was observed between KMT2A expression and the stemness-related gene sets, including tumor stemness-related signature (CD44/CD133/Sox2/OCT4) and gastric cancer-specific stemness signature (Sox/FOXM1). This evidence concerns the gene PROM1 and neoplasm.