HPSE and cancer: Aberrant glycosylation, demonstrated by binding of the lectin HPA, is linked to invasion and poor prognosis in many human cancers, including breast cancer.[21] Importantly, a growing number of studies have demonstrated that aberrant glycosylation may be associated with treatment failure in patients following radiotherapy.[23,24] As shown inFigure 2, we observed that cells exposed to IR have increased HPA immunopositivity.