For example, the commonly used mood stabilizer lithium carbonate can inhibit thyroid hormones by inhibiting the coupling of iodinated tyrosine, inhibiting iodine uptake, altering the structure of thyroglobulin, reduce thyroxine release, interfering with T3 and eT4 deiodination, altering cellular response to thyroid response of the thyroid, etc. A previous study showed that 0–47% (mean 10%) of patients on long-term lithium carbonate had hypothyroidism (14). Here, TG is linked to hypothyroidism.