IGF1R and B-cell chronic lymphocytic leukemia: The CWL ChIP-Seq workflow proved effective in detecting the statistically significant, differential binding of EZH2 to the promoter region of the IGF1R gene in U-CLL compared to M-CLL (FDR-adjusted p-value <0.001 for peaks chr15:98650048-98650448 and chr15:98648126-98648526) (Figure 3 and Supplementary Figure S4), while at the same time the levels of H3K27me3 remained unchanged between the two subgroups for the same region (Supplementary Figure S5).