It is of note that we successfully detected the differentially expressed TP63 (FDR-adjusted p-value <0.001), as this gene was reported to be hypomethylated and overexpressed in subset #8, and its encoded protein (p63) was shown to act as a pro-survival factor in CLL models in vitro (Papakonstantinou et al., 2019). Here, TP63 is linked to B-cell chronic lymphocytic leukemia.