The CWL ChIP-Seq workflow proved effective in detecting the statistically significant, differential binding of EZH2 to the promoter region of the IGF1R gene in U-CLL compared to M-CLL (FDR-adjusted p-value <0.001 for peaks chr15:98650048-98650448 and chr15:98648126-98648526) (Figure 3 and Supplementary Figure S4), while at the same time the levels of H3K27me3 remained unchanged between the two subgroups for the same region (Supplementary Figure S5). The gene discussed is EZH2; the disease is B-cell chronic lymphocytic leukemia.