ESR2 and Anxiety: In addition to the downregulation of LHb Cav3.3 calcium channel expression (Song et al., 2018), estrogen exposure reduces LHb neuronal activation (Li et al., 2015), and local administration of an ERβ agonist, diarylpropionitrile, to the LHb reverses ovariectomy-induced increases in both behavioral measures of anxiety and baseline LHb cFos production (Liu et al., 2022a).