Interestingly, only CHL1−/− males showed more stress-related behavior after quinpirole treatment and only CHL1−/− females exhibited hypolocomotion and altered anxiety- and stress-related behavior when treated with sulpiride, suggesting that the interaction of CHL1 with D2R modifies exploratory and locomotor activity as well as emotional behavior differently in males and females. The gene discussed is DRD2; the disease is Anxiety.