Since CHL1 interacts with D2R and regulates its levels at the cell surface (Kotarska et al., 2020), and since CHL1 is also implicated in autism spectrum disorders (Salyakina et al., 2011; Mandic-Maravic et al., 2022), we investigated if treatment of CHL1+/+ and CHL1−/− mice with quinpirole or sulpiride alters their social behavior. Here, DRD2 is linked to autism spectrum disorder.