Interest in novelty, spatial working memory, social interaction and anxiety-related behavior were not different between vehicle- and quinpirole-treated CHL1+/+ and CHL1−/− males and females, while sulpiride treatment enhanced the number of visits at the familiar and unfamiliar mouse by CHL1+/+ males and CHL−/− males but not CHL−/− females. The gene discussed is CHL1; the disease is Anxiety.