CHL1 and schizophrenia: The sex-specific behavioral differences in CHL1−/− mice and CHL1’s implication in schizophrenia and autism spectrum disorders (Sakurai et al., 2002; Frints et al., 2003; Chen et al., 2005; Tam et al., 2010; Salyakina et al., 2011; Shoukier et al., 2013) suggests that CHL1 participates in sex-dependent regulation of DA-dependent pathways in the dorsal and ventral striatum.