Almost half of PBC patients (11) had associated positive AMA and positive anti-gp210 and/or anti-Sp100, while 26.3% of them (5) had only positive AMA (Table 2).<h4>Conclusion</h4>The findings in this work support the role of anti-gp 210 and anti-Sp100 in identifying patients with PBC and overlap syndromes. The gene discussed is NUP210; the disease is primary biliary cholangitis.