Along those lines, ACI-5891 has been previously reported to mitigate TDP-43 aggregation and provide neuroprotection in in vitro and in vivo models of TDP-43 proteinopathies without altering the intracellular functions of TDP-43.28 This study expands the understanding of the mode of action of the humanized version of ACI-5891 in the patient CNS compartment to capture and clear the seeding species. The gene discussed is TARDBP; the disease is proteostasis deficiencies.