The exact relationship between an increase in the PACAP receptor PAC1 that is present on astrocytes and increased expression of astrocytic genes such as ALDH1L1, and their effects, needs further study, since astrocytic dysfunctionality has been previously linked to the development and pathophysiology of schizophrenia (Mei et al., 2018). This evidence concerns the gene ALDH1L1 and schizophrenia.