Findings from ischemic stroke studies have highlighted that specific ECM components including CSPGs, fibronectin, thrombospondin, tenascin-C and laminins are elevated and exacerbate injury by enhancing neuroinflammation in the perihematomal area (Jucker et al., 1993; Sakai et al., 2001; Li et al., 2012). Here, TNC is linked to ischemic stroke.