AKT1 and early-onset autosomal dominant Alzheimer disease: These subnetworks were related to metabolic pathways (n = 28), oxidative phosphorylation (n = 10), Alzheimer’s disease (n = 9), protein processing in the endoplasmic reticulum (n = 6), PI3K-Akt signaling pathway (n = 6), MAPK signaling pathway (n = 5), and GABAergic synapses (n = 5) in the DM group.