Among their gene targets are several members of the EGFR pathway, notably KRAS and BRAF.43As identified, mir-143 and mir-145 orchestrate a well-coordinated program of gene repression, where either they share a target transcript, or both their target transcripts converge in a common signaling cascade.44In addition, Let-7 microRNA is a well-known tumor-suppressor molecule that regulates EGFR. The gene discussed is EGFR; the disease is neoplasm.