APC and cancer: Therefore, enhanced Mir-135 family expression implies upregulation of Wnt pathway and is associated with advanced tumor grade and poor clinical outcome.29, 30Colonic cancer progression via immediate inhibition of APC gene is also clear and extensively validated for miR-494 and miR-19.31, 32In addition, mir-21, which is among the most famous oncomirs, shows positive expressional correlation with key components of Wnt pathway including b-catenin and cyclin D1.