As experimentally revealed, mir-504 overexpression promotes colon cancer tumorigenicity in vivo.65Actually, translational repression of TP53 is controlled by a wide variety of microRNAs including mir-125b, mir-25, mir122, mir-30d, and mir-518c.64MicroRNA-125b is a brain-enriched tiny RNA that acts as negative regulator of p53 in both zebrafish and humans.66In vitro overexpression of Mir-125b reduces endogenous levels of p53 protein and impairs physiological apoptosis during development and stress response. This evidence concerns the gene TP53 and colonic neoplasm.