Moreover, through animal model experiments, mir-497 was also identified to exhibit antiproliferative and antiapoptotic action by targeting VEGF receptor 2 in colonic tissues.57Furthermore, a very recently published study revealed the significant involvement of mir-27b in the control of PIK3CA signaling cascade.58Overexpression of this molecule inhibits colorectal tumor cells proliferation and migration, via suppressing PI3K p110a subunit. Here, PIK3CA is linked to colorectal neoplasm.