This phenomenon was further supported by animal-based models that revealed Dicer1, which is key enzyme of physiological microRNA biogenesis, as a major tumor-suppressor gene in CRC cell lines.23Nevertheless, that issue still remains ambiguous and highly controversial.24Interestingly, a work by Wang et al found the majority of microRNA expression to be globally elevated in CRC.25Converging with these findings, more recent studies of microRNA profiles in CRC indicated that approximately two-third of altered microRNAs in CRC have shown enhanced expression. Here, DICER1 is linked to colorectal carcinoma.