For example, mir-19, mir-217, and mir-181d can inhibit angiogenesis, proliferation, and invasion of colorectal tumors by interacting with downstream regulators like PEAK1.47, 48, 49On the other hand, mir-31 appears to be a potent stimulator of KRAS in colorectal tumors, through negative regulation of RASA1, which is inhibitor of KRAS function.50Furthermore, mir-210 and mir-181a constitute closely related with KRAS activation molecules, as significant oncomirs that promote CRC progression and invasiveness.51 This evidence concerns the gene PEAK1 and colorectal neoplasm.