Moreover, through animal model experiments, mir-497 was also identified to exhibit antiproliferative and antiapoptotic action by targeting VEGF receptor 2 in colonic tissues.57Furthermore, a very recently published study revealed the significant involvement of mir-27b in the control of PIK3CA signaling cascade.58Overexpression of this molecule inhibits colorectal tumor cells proliferation and migration, via suppressing PI3K p110a subunit. This evidence concerns the gene PIK3CG and colorectal neoplasm.