PTEN and colorectal carcinoma: For instance, miR-17–92 cluster, also known as oncomir-1, directly targets 3′UTR and inhibits PTEN gene, driving aberrant cell proliferation and atypical angiogenesis.53Furthermore, mir-21, mir-19, and mir-96 are important oncogenes also found to be involved in CRC carcinogenesis through stimulation of AKT/PIK3 pathway.54In addition, mir-126 is a significant tumor-suppressor gene with crucial implications in the control of EGFR signaling.