EGFR and neoplasm: It constitutes a well-characterized pathway with critical role in the survival, proliferation, migration, angiogenesis, and apoptosis of human cells, involved in several types of epithelial cancers including CRC.41A series of investigations in the field revealed the extensive implication of microRNAs in regulation of EGFR signaling that significantly enhanced our detailed understanding of intestinal carcinogenesis.42Two of the most important EGFR-related microRNA tumor-suppressor genes are mir-143 and mir-145.