MSH6 and colorectal carcinoma: Although, the microRNA profiles of CRC have been studied extensively, comparatively few analyses have specifically investigated microRNA signatures in the presence of MSI.73Nevertheless, certain microRNAs have recently emerged as significant regulators of genes associated with MMR, including MLH1, MSH2, MSH6, and PMS2.74Valeri et al identified that mir-155 compromises MMR mission by targeting the 3′UTR of MLH1, MSH2, and MSH6.75Overexpression of this molecule correlated with a hypermutated phenotype and MSI in CRC cell lines.