SOST and type 2 diabetes mellitus: Importantly, glucose increases SOST expression and sclerostin content in cultured osteocyte‐like IDG‐SW3 cells, which was validated in vivo and ex vivo in streptozotocin‐induced hyperglycemic rats.(18) Further, it was demonstrated that sclerostin directly promotes the resorption of the perilacunar matrix, a process called osteocytic osteolysis.(19, 20) These findings support that T2D may influence osteocyte function and subsequently bone remodeling.