SOST and Hyperglycemia: After mechanical unloading, osteocytes secrete sclerostin, which inhibits bone formation by blocking Wnt signaling.(15) Although serum sclerostin levels and insulin sensitivity were not associated in healthy and prediabetic men,(16) sclerostin levels are increased in overt T2D.(17) This indicates that hyperglycemia changes the function of osteocytes and the lacunocanalicular network, which may lead to lower bone remodeling and higher cortical porosity in T2D.