CALCA and type 2 diabetes mellitus: There have been suggestions of a direct effect on osteoclasts and osteoblasts through intracellular signaling pathways(98, 99) or indirect effect on bone cells through thyroid c cells and calcitonin‐dependent inhibition of bone resorption.(100) Moreover, a potential incretin‐mediated decrease of the chronic inflammation in T2D, which is believed to negatively modify bone tissue by nonenzymatic glycosylation, mineralization imbalance, and bone microdamage, has been suggested.(99) See Figure 2 for an overview of the cellular mechanisms.