The ZDF model harbors a leptin receptor mutation to induce hyperglycemia.(26) Although this model recapitulates many T2DM disease characteristics, leptin receptor mutations are rare in humans.(27) Therefore, the current study utilized the Zucker Diabetic‐Sprague Dawley (ZDSD) rat model of T2DM, a model that develops progressive hyperglycemia and obesity without leptin receptor mutations.(28) We investigated the effects of T2DM on implant osseointegration, peri‐implant bone structure and matrix composition, and fixation strength by comparing ZDSD rats to Sprague Dawley controls. The gene discussed is LEPR; the disease is Obesity.