MSTN and diabetes mellitus: Muscle mass and bone mass are closely related during development and growth, and muscle and bone interact through mechanical, endocrine, and paracrine factors in physiologic and disease states.(16, 17) Myokines, which are factors secreted by skeletal muscle, contribute to muscle‐bone communication and have even been associated with direct effects on bone and bone cells.(18) Myokines can be dysregulated in several disease states, including diabetes.(19) Myostatin, which has been found to be systemically elevated in humans with T1D(20, 21) is a member of the TGF‐β family.