Diabetic bone disease (DBD), considered now a serious complication associated with T1D, is characterized by decreased bone mineral density,(2) impaired bone microarchitecture,(3) and an increase in risk of fracture.(4, 5) Bone mass and bone size are negatively affected in adolescents with T1D,(6, 7) and those with T1D exhibit fractures throughout the life span,(8) despite advancements in insulin therapy. Here, INS is linked to type 1 diabetes mellitus.