Physical exercise has shown beneficial effects, including improved glucose metabolism and insulin sensitivity and is often recommended along with pharmacotherapies for the clinical management of diabetes.(16) An acute bout of exercise increases muscle glucose uptake efficiency, and chronic exercise training enhances mitochondrial biogenesis, increasing the expression levels of glucose transporter proteins and various metabolic genes.(17) Furthermore, the contractions of muscles can have a positive impact on the metabolism of other tissues and organs, including bone. This evidence concerns the gene INS and diabetes mellitus.