On the other hand, certain parameters had prognostic value but lacked statistical significance, including the onset anemia and/ or leukocytosis, early lymphopenia, LDH level, hypoalbuminemia, diverse grades of BCL2 expression (++ and +++), the presence of PD1, and the association of CD68 in relation to distance and proximity. This evidence concerns the gene PDCD1 and Increased total leukocyte count.