The prospective component allowed the analysis of cases from a perspective that focused on parameters reflecting the biology of the tumor process (overexpression of BCL2 in malignant cells, presence of PD1 on T lymphocytes, CD68+ macrophages in the tumor microenvironment, and the presence of EGFR with regards to its role in angiogenesis stimulation. The gene discussed is EGFR; the disease is neoplasm.