The high VEGF expression and endometriosis lesion extent in this study were due to the inhibition of VEGF production in one pathway, namely NF-kB, which was inhibited by flavonoids in the ethanol extract of basil leaves, while in the MAPK pathway, there was no inhibition of VEGF production; thus there was an increase. The gene discussed is NFKB1; the disease is endometriosis.