SOD1 and Insulin resistance: Furthermore, PCOS-associated insulin resistance and hyperglycemiaresult in extreme lipid peroxidation, an increase in free radicals,and an exhaustion of antioxidants and are thereby related with inducedoxidative stress in the reproductive tissue.44 Since lipid peroxidation results in free radical damage to the cellmembrane components and induces inflammation and cell necrosis, itis frequently utilized as a marker for oxidative tissue damage.45 PCOS group in the present study had a significantlyhigher MDA level and lower SOD, CAT, and GSH activity.